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- Title
Thiophene ring-opening reactions VI. Attempted cyclization towards [fused]-tricyclic system involving a thiolate anion and suitably located electrophilic carbon.
- Authors
Abdullah, Ahmad H.; Zahra, Jalal A.; Sabri, Salim S.; Awwadi, Firas F.; Hussein, Ahmad Q.; El-Abadelah, Mustafa M.
- Abstract
Model α-chloro-β-nitrothieno[2,3-c]pyridazines incorporating N1-(aryl) entity appended with ortho-methoxycarbonyl or trifluoromethyl group were prepared via intramolecular cyclization of their respective N-arylhydrazone precursors. Interaction of these substrates with N′-(p-fluorophenyl)benzothiohydrazide, in the presence of NEt3, furnished the respective 1,3,4-thiadiazoline–pyridazine thiolate hybrids that were S-methylated to produce the corresponding "sulfanyl" derivatives. Their structures were deduced from spectral data, and confirmed by single-crystal X-ray diffraction.
- Subjects
RING-opening reactions; RING formation (Chemistry); ANIONS; X-ray diffraction; CARBON; PYRIDAZINES
- Publication
Zeitschrift für Naturforschung. Section C: A Journal of Biosciences, 2023, Vol 78, Issue 3/4, p133
- ISSN
0939-5075
- Publication type
Article
- DOI
10.1515/znc-2022-0080