We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical and pathological characteristics of incidental and nonincidental papillary thyroid microcarcinoma in 339 patients.
- Authors
Vasileiadis, Ioannis; Karatzas, Theodore; Vasileiadis, Dimitrios; Kapetanakis, Stylianos; Charitoudis, Georgios; Karakostas, Efthimios; Kouraklis, Gregory
- Abstract
Background We analyzed the incidence and the clinicopathological characteristics of papillary thyroid microcarcinoma (PTMC) in a high prevalence region of goiter with the purpose to investigate differences between incidental and nonincidental PTMC. Methods A total of 2236 patients who underwent total thyroidectomy from 2001 to 2009 were reviewed retrospectively. Papillary carcinoma was diagnosed in 583 patients. Of these, 339 patients with PTMC were included in the study. Clinicopathological features were evaluated by univariate and multivariate analysis. Results The prevalence of incidental PTMC was 12% of all patients who underwent surgery for thyroid disease. Univariate analysis showed that bilaterality ( p = .001), autoimmune thyroid disease ( p = .049), size of tumor >5 mm ( p < .001), multifocality ( p < .001), lymph node metastasis ( p < .001), and capsule invasion ( p < .001) were significantly associated with nonincidental PTMC. The incidence of lymph node metastasis in incidental PTMC was 5% versus 33% in nonincidental, suggesting that the biological behavior may be different in the 2 categories. Conclusion Our results indicate that a high rate of PTMC presented 1 or more risk factors including multifocality, bilaterality, capsule invasion, and lymph node metastasis. Therefore, we suggest total thyroidectomy followed by adequate exploration of the central neck compartment for possible nodal involvement and resection as a safe therapeutic approach. © 2013 Wiley Periodicals, Inc. Head Neck 36: 564-570, 2014
- Subjects
LYMPHATICS; PAPILLARY carcinoma; PATHOLOGY; CANCER invasiveness; THYROIDECTOMY
- Publication
Head & Neck, 2014, Vol 36, Issue 4, p564
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23333