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- Title
Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy.
- Authors
Lau, Harold Y.; Brar, Sony; Klimowicz, Alexander C.; Petrillo, Stephanie K.; Hao, Desirée; Brockton, Nigel T.; Kong, Christina S.; Lees-Miller, Susan P.; Magliocco, Anthony M.
- Abstract
Background. Human papillomavirus (HPV)-related squamous cell cancer of the head and neck (SCCHN) has emerged as a distinct clinical entity. The expression of p16 protein can be used as a surrogate for HPV status. Methods. p16 immunohistochemistry (IHC) was assessed in archival paraffin-embedded material for 55 patients with locally advanced SCCHN treated with a uniform regimen of cisplatin and radiation. HPV status was assessed by colorimetric in situ hybridization (CISH) and polymerase chain reaction (PCR). Results. Compared with p16- and HPV-negative patients, the p16- and HPV-positive patients had improved overall survival, disease-free survival, and locoregional recurrence rates. Conclusions. p16 IHC may serve as a useful surrogate and prognostic marker for patients with HPV-related SCCHN treated with cisplatin and radiation.
- Subjects
SQUAMOUS cell carcinoma; CISPLATIN; RADIOTHERAPY; TUMOR proteins; IMMUNOHISTOCHEMISTRY; DRUG therapy; GENETICS
- Publication
Head & Neck, 2011, Vol 33, Issue 2, p251
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.21439