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- Title
Clinical outcome in bipolar disorder in a community-based follow-up study in Butajira, Ethiopia.
- Authors
Fekadu, A.; Kebede, D.; Alem, A.; Fekadu, D.; Mogga, S.; Negash, A.; Medhin, G.; Beyero, T.; Shibre, T.
- Abstract
Objective: To determine the clinical outcome of bipolar disorder in a developing country setup. Method: After assessing 68 378 individuals, aged 15–49 years, in a double-sampling design in a rural community in Ethiopia, 312 patients with bipolar disorder were prospectively monitored with symptom rating scales and clinically for an average of 2.5 years. Results: Overall, 65.9% of the cohort experienced a relapse – 47.8% manic, 44.3% depressive and 7.7% mixed episodes – and 31.1% had persistent illness. Female gender predicted depressive relapse, while male gender predicted manic relapse. Being on psychotropic medication was associated with remission. Conclusion: This large community-based study confirms the relapsing nature of bipolar disorder and a tendency for chronicity. This may be partly because of lack of appropriate interventions in this setting; however, it may also indicate the underlying severity of the disorder irrespective of setting.
- Subjects
ANTIPSYCHOTIC agents; BIPOLAR disorder; AFFECTIVE disorders; DEVELOPING countries; REMISSION (Civil law)
- Publication
Acta Psychiatrica Scandinavica, 2006, Vol 114, Issue 6, p426
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/j.1600-0447.2006.00825.x