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- Title
Prognostic and clinicopathological significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma: Systematic review and meta‐analysis.
- Authors
Ramos‐García, Pablo; González‐Moles, Miguel Ángel; Gil‐Montoya, José Antonio; Ruiz‐Ávila, Isabel; Ayén, Ángela; González‐Ruiz, Lucía
- Abstract
Background: To evaluate the prognostic significance of CTTN/cortactin alterations in head and neck squamous cell carcinoma (HNSCC). Material and methods: We searched PubMed, Embase, Web of Science, and Scopus for studies published before May 2018. We conducted a meta‐analysis to quantify the impact of CTTN/cortactin alterations on clinicopathological and survival variables. Results: Eighteen studies (1633 patients) met inclusion criteria. Quantitative evaluation revealed a strong association of CTTN/cortactin alterations with N+ status (P < .001), higher T status (P < .001), advanced clinical stage (P < .001), high histological grade (P = .001), and lower overall survival (OS) (P < .001). We found heterogeneity in T status, histological grade, and OS and observed small‐study effects on N status and OS. In subgroup analyses, a significant association of CTTN amplification and cortactin overexpression with the above variables was preserved. The strongest association between CTTN/cortactin alterations and a worse outcome was observed in the subgroups of Asian patients and pharyngolaryngeal squamous cell carcinomas. Conclusions: CTTN/cortactin alterations should be evaluated to predict the HNSCC prognosis.
- Subjects
SQUAMOUS cell carcinoma; META-analysis; HEAD &; neck cancer
- Publication
Head & Neck, 2019, Vol 41, Issue 6, p1963
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25632