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- Title
Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation.
- Authors
Iyer, N. Gopalakrishna; Kim, Leslie; Nixon, Iain J.; Palmer, Frank; Shah, Jatin P.; Patel, Snehal G.; Ganly, Ian
- Abstract
Background Existing treatment regimens for squamous cell carcinoma (SCC) of the base of tongue (BOT) favor chemoradiation. However, there is a shifting paradigm toward minimally invasive surgery with adjuvant radiatiotherapy for select tumors. The aim was to report our experience in conventional surgical management with particular focus on T1/T2 tumors, which may be candidates for minimally invasive techniques. Methods Between 1985 and 2005, 128 patients were treated with primary surgery. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were calculated using Kaplan-Meier method, and predictive factors analyzed by univariate and multivariate analyses. Results Five-year OS, DSS, and RFS rates were 60%, 70%, and 61%, respectively. Multivariate analysis showed pathologic T classification and extracapsular extension (ECE) were significant predictors for DSS, whereas T classification remained significant for local recurrence. DSS for T1/T2 tumors ranged from 77% (node-positive) to 84% (node-negative). Conclusion T classification and ECE are independent predictors of outcome for BOT SCC. Patients with cT1/T2 tumors had excellent outcome and may be suitable for transoral robotic or endoscopic surgical procedures. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
- Subjects
CANCER patients; SQUAMOUS cell carcinoma; POSTOPERATIVE care; RADIATION; KAPLAN-Meier estimator
- Publication
Head & Neck, 2013, Vol 35, Issue 7, p999
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.23071