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- Title
The gingival inflammatory infiltrate in cardiac patients treated with calcium antagonists*.
- Authors
Bullón, Pedro; Machuca, Guillermo; Armas, José R.; Rojas, José L.; Jiménez, Gema
- Abstract
Abstract Objectives: To analyse the periodontal inflammatory infiltrates in patients with cardiac disease, some of these patients were treated with calcium antagonists (nifedipine and diltiazem) and some were not, to compare them with a healthy control group, and to evaluate the changes in the inflammatory infiltrate after periodontal treatment. Material and methods: A “healthy group” (HG, n=12), a “cardiac group” (CG, n=12) without treatment with calcium antagonists, a “nifedipine group” (NG, n=18) and a “diltiazem group” (DG, n=13) were analysed. Biopsies were taken from a zone 2–3 mm below the upper part of the interproximal papillae 12–13 and 33–32 before causal periodontal treatment and after 1 year. Using haematoxylin-eosin staining, the plasma cells (P), lymphocytes (L), histiocytes (H) and polymorphonuclear cells (PMN) were counted. T and B lymphocytes were evaluated using the monoclonal antibodies anti-CD20 and anti-CD45RO. Statistical tests used: χ2 for study of the sample composition; ANOVA for comparison between groups; Student t-test and Wilcoxon test for comparison between visits; post-hoc test Bonferroni. Results: When the cells were compared statistically, differences were stablished for L at the first visit (p<0.00001) and at the last visit (p<0.02), for the B lymphocytes (first visit p<0.0021, last visit p<0.022) and for the T lymphocytes (first visit p<0.0042, last visit p<0.0021). Between the 2 visits, HG showed significant reductions for P (p<0.01), L (p<0.045) and H (p<0.033); and the NG for L (p<0.0001). Lymphocytes showed differences in the NG with respect to the B lymphocytes (p<0.008). Conclusions: Nifedipine affects the inflammatory infiltrate with a greater number of lymphocytes (especially B) and these cells fell significantly in number after periodontal treatment.
- Subjects
HEART diseases; THERAPEUTICS; PERIODONTITIS; CALCIUM antagonists; DRUG side effects; DISEASE risk factors
- Publication
Journal of Clinical Periodontology, 2001, Vol 28, Issue 10, p897
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1034/j.1600-051X.2001.028010897.x