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- Title
Children conceived after intracytoplasmic sperm injection (ICSI): is there a role for the paediatrician?
- Authors
Mau, C.; Juul, A.; Main, K. M.; Loft, A.
- Abstract
Aim: The aim of the study was to evaluate current medical knowledge about children born after intracytoplasmic sperm injection (ICSI) with respect to congenital malformations, chromosome abnormalities and postnatal growth. Results: The total malformation rate in children conceived after ICSI was comparable to the background population in nine of the 11 articles studied. In two of the studies, a significant increase in congenital malformations was found. More specifically, children born after ICSI appear to have a higher risk of urogenital malformations, especially hypospadias, which may be related to paternal subfertility. There is insufficient knowledge about chromosomal or genetic anomalies and auxological data in children born after ICSI. The methodological approach to follow-up the children was inconsistent, as the clinical examinations were not done with standardized ascertainment. Conclusion: Paediatricians and obstetricians should collaborate with fertility clinics to obtain valid longitudinal observations with respect to congenital malformations, neurological development, growth, pubertal maturation, fertility and morbidity in children conceived by ICSI.
- Subjects
HYPOSPADIAS; CHILDREN; DISEASE risk factors; PENIS abnormalities; HUMAN fertility; HUMAN abnormalities
- Publication
Acta Paediatrica, 2004, Vol 93, Issue 9, p1238
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1111/j.1651-2227.2004.tb02756.x