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- Title
Alteration of biochemical profiles after high-dose intravenous immunoglobulin administration in Kawasaki disease.
- Authors
Lee, KY; Han, JW; Lee, JS; Whang, KT; Lee, K Y; Han, J W; Lee, J S; Whang, K T
- Abstract
<bold>Unlabelled: </bold>Intravenous immunoglobulin (IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. Early effects of high-dose IVIG treatment on biochemical profiles including lipids and proteins were evaluated in patients with Kawasaki disease (KD). Twelve children with KD (9 boys) were treated with IVIG at 2 g/kg over a period of 12 h. Serial sera samples were collected from the patients four times: before IVIG treatment and 2 h, 24 h and 7 d after IVIG treatment. The samples were frozen at -20 degrees C before biochemical analysis. A significant decrease in albumin concentration was found 2 h and 24 h after IVIG treatment, but this recovered to the pretreatment level after 7 d. Total cholesterol and triglyceride increased slightly after 7 d. A significant decrease in HDL-cholesterol and C-reactive protein was seen 2 h and 24 h after IVIG treatment.<bold>Conclusion: </bold>High-dose IVIG affects immediate changes in protein profiles and HDL-cholesterol in KD. Changes in HDL-cholesterol induced by IVIG may be the result of changes in systemic protein metabolism.
- Subjects
THERAPEUTIC use of immunoglobulins; IMMUNE complex diseases; MUCOCUTANEOUS lymph node syndrome; JUVENILE diseases; THERAPEUTICS; C-reactive protein; HIGH density lipoproteins; IMMUNOGLOBULINS
- Publication
Acta Paediatrica, 2002, Vol 91, Issue 2, p164
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1080/080352502317285153