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- Title
Appetite Changes in Weight Regain and Weight Maintenance After Roux-en-Y Gastric Bypass.
- Authors
McInnis, Kurt; Brown, Jennifer L.; Finlayson, Graham; Dent, Robert; Doucet, Éric
- Abstract
Purpose: Roux-en-Y gastric bypass (RYGB) surgery produces significant weight loss. However, a number of patients experience weight regain years after surgery. Factors driving weight regain after surgical interventions are currently being explored. Our objective was to investigate appetite-related measures associated with weight regain after RYGB surgery. Materials and Methods: Using a cross-sectional design, 29 participants (49.6 ± 9.1 years of age; current BMI 32.4 ± 4.7 kg/m2, 43.6 ± 8.9 months post-RYGB) were stratified into tertiles according to weight regain per month after nadir (weight maintenance (WM), n = 9; low weight regain (LWR), n = 10; and high weight regain (HWR), n = 10). The average weight regain was, by design, significantly different between the groups (WM = 2.2 ± 2.5 kg; LWR = 10.0 ± 3.4 kg; HWR = 14.9 ± 6.3 kg regained, p < 0.05). Appetite (visual analog scales), olfactory performance ("sniffin sticks"), eating behaviors (Three Factor Eating Questionnaire), food reward (Leeds Food Preference Questionnaire), and appetite-related hormones (ghrelin, PYY, GLP-1 and leptin) were measured fasting and in response to a standardized test meal. Results: Dietary restraint was significantly higher than clinical cutoffs in WM and LWR (p < 0.05). As expected, significant time effects were noted for ghrelin, PYY, and GLP-1, but there were no group differences. Conclusion: The results suggest that appetite-related outcomes are similar across individuals who have maintained weight loss and experienced regain following RYGB.
- Subjects
GASTRIC bypass; APPETITE disorders; FOOD habits; REWARD (Psychology); WEIGHT loss; FOOD preferences
- Publication
Obesity Surgery, 2022, Vol 32, Issue 7, p1
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-022-06061-5