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- Title
Upregulation of Ghrelin Gene Expression in the Excluded Stomach of Obese Women with Type 2 Diabetes After Roux-en-Y Gastric Bypass in the SURMetaGIT Study.
- Authors
Fonseca, Danielle Cristina; Sala, Priscila; Torrinhas, Raquel Susana; Waitzberg, Dan Linetzky; Singer, Joelle; Singer, Pierre
- Abstract
Background: Mechanisms of type 2 diabetes remission (T2Dr) after Roux-en-Y gastric bypass (RYGB) in obese patients appear to involve gastrointestinal hormones.Objective: The objective of this study is to explore changes in ghrelin plasma levels and ghrelin gastrointestinal gene expression (GHRL) after RYGB, and their relationships to T2Dr.Setting: In 20 obese women with T2D, before and 3 months after RYGB, we assessed GHRL expression by microarray and quantitative RT-PCR in gastrointestinal biopsy samples and plasma levels of ghrelin.Results: After RYGB, GHRL expression increased in the excluded stomach (<italic>p</italic> < 0.05) with no change in other gastrointestinal sites. There were no significant changes in ghrelin plasma levels and no correlations with T2Dr.Conclusions: After RYGB, over-expression of GHRL gene occurs only in the excluded stomach with no correlation to T2Dr.
- Subjects
GASTRIC bypass; GHRELIN; GENE expression; GASTROINTESTINAL system; TYPE 2 diabetes
- Publication
Obesity Surgery, 2018, Vol 28, Issue 3, p877
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-017-3098-3