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- Title
Sagittal Abdominal Diameter and Visceral Adiposity.
- Authors
Gletsu-Miller, Nana; Kahn, Henry; Gasevic, Danijela; Liang, Zhe; Frediani, Jennifer; Torres, William; Ziegler, Thomas; Phillips, Lawrence; Lin, Edward
- Abstract
Background: In the context of increasing obesity prevalence, the relationship between large visceral adipose tissue (VAT) volumes and type 2 diabetes mellitus (T2DM) is unclear. In a clinical sample of severely obese women (mean body mass index [BMI], 46 kg/m) with fasting normoglycemia ( n = 40) or dysglycemia (impaired fasting glucose + diabetes; n = 20), we sought to determine the usefulness of anthropometric correlates of VAT and associations with dysglycemia. Methods: VAT volume was estimated using multi-slice computer tomography; anthropometric surrogates included sagittal abdominal diameter (SAD), waist circumference (WC) and BMI. Insulin sensitivity (Si), and beta-cell dysfunction, measured by insulin secretion (AIRg) and the disposition index (DI), were determined by frequently sampled intravenous glucose tolerance test. Results: Compared to fasting normoglycemic women, individuals with dysglycemia had greater VAT ( P < 0.001) and SAD ( P = 0.04), but BMI, total adiposity and Si were similar. VAT was inversely associated with AIRg and DI after controlling for ancestry, Si, and total adiposity (standardized beta, −0.32 and −0.34, both P < 0.05). In addition, SAD (beta = 0.41, P = 0.02) was found to be a better estimate of VAT volume than WC (beta = 0.32, P = 0.08) after controlling for covariates. Receiver operating characteristic analysis showed that VAT volume, followed by SAD, outperformed WC and BMI in identifying dysglycemic participants. Conclusions: Increasing VAT is associated with beta-cell dysfunction and dysglycemia in very obese women. In the presence of severe obesity, SAD is a simple surrogate of VAT, and an indicator of glucose dysregulation.
- Subjects
OBESITY; ADIPOSE tissues; INSULIN resistance; WAIST circumference; BODY mass index; COMPUTED tomography
- Publication
Obesity Surgery, 2013, Vol 23, Issue 7, p874
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-013-0874-6