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- Title
Novel β-galactosidase-specific O<sup>2</sup>-glycosylated diazeniumdiolate probes.
- Authors
Bedell, Barry J.; Bohle, D. Scott; Chua, Zhijie; Czerniewski, Alexander; Evans, Alan C.; Mzengeza, Shadreck
- Abstract
Three β-galactosidase-specific nitric-oxide-releasing diazeniumdiolate conjugated probes were prepared as a prelude to studies of new potential molecular MRI imaging agents. A glycosylated derivative, 2e, designed to be trafficked across cell membranes, was also prepared. We report, in detail, the synthesis and characterization of these probes. In addition, the release of diazeniumdiolate from the probes by β-galactosidase-catalyzed hydrolysis was used to estimate their efficacy as serum-stable, specific NO donors.
- Subjects
HYDROLASES; NITRIC oxide; MAGNETIC resonance imaging; CELL membranes; HYDROLYSIS; SERUM; OXYGEN; CYTOCHROMES; CHYMOTRYPSIN
- Publication
Canadian Journal of Chemistry, 2010, Vol 88, Issue 9, p969
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/V10-087