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- Title
High-dose vitamin D supplementation is associated with an improvement in several cardio-metabolic risk factors in adolescent girls: a nine-week follow-up study.
- Authors
Khayyatzadeh, Sayyed Saeed; Mirmoosavi, Seyed Jamal; Fazeli, Mostafa; Abasalti, Zahra; Avan, Amir; Javandoost, Ali; Rahmani, Farzad; Tayefi, Maryam; Hanachi, Parichehr; Ferns, Gordon A.; Bahrami-Taghanaki, Hamidreza; Ghayour-Mobarhan, Majid
- Abstract
Background Vitamin D deficiency is a prevalent and important global health problem. Because of its role in growth and development, vitamin D status is likely to be particularly important in adolescent girls. Here, we explored the effects of high-dose vitamin D supplementation on cardio-metabolic risk factors. Methods We have examined the effects of vitamin D supplementation on cardio-metabolic risk factors in 988 healthy adolescent girls in Iran. Fasting blood samples and anthropometric measurements were obtained at baseline and after supplementation with high-dose vitamin D. All individuals took a capsule of 50,000 IU vitamin D/week for nine weeks. The study was completed by 940 participants. Results The prevalence of vitamin D deficiency was 90% at baseline, reducing to 16.3% after vitamin D supplementation. Vitamin supplementation was associated with a significant increase in serum concentrations of 25 (OH) vitamin D and calcium. There were significant reductions in diastolic blood pressure, heart rate, waist circumference and serum fasting blood glucose, total- and low-density lipoprotein-cholesterol after the nine-week period on vitamin D treatment, but no significant effects were observed on body mass index, systolic blood pressure or serum high-density lipoprotein cholesterol and triglyceride. Conclusion Vitamin D supplementation had beneficial effects on cardio-metabolic profile in adolescent girls.
- Subjects
PHYSIOLOGICAL effects of vitamin D; HEART disease risk factors; TEENAGE girls' health; LOW density lipoprotein absorption &; adsorption; PHYSIOLOGICAL effects of cholesterol
- Publication
Annals of Clinical Biochemistry, 2018, Vol 55, Issue 2, p227
- ISSN
0004-5632
- Publication type
journal article
- DOI
10.1177/0004563217707784