We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
VPS35 Parkinson's disease phenotype resembles the sporadic disease.
- Authors
Struhal, Walter; Presslauer, Stefan; Spielberger, Sabine; Zimprich, Alexander; Auff, Eduard; Bruecke, Thomas; Poewe, Werner; Ransmayr, Gerhard
- Abstract
Recently a new autosomal dominant Parkinson's disease mutation (p.Asp620Asn) in the VPS35 gene was discovered. The clinical features of 14 PD patients with this mutation from three Austrian families were evaluated. Age at disease-onset appears lower and depression was more common in Austrian patients compared to sporadic PD patients. However, we were unable to identify a specific clinical maker of VPS35 patients, who otherwise resemble sporadic PD patients.
- Subjects
PARKINSON'S disease; PHENOTYPES; CEREBRAL amyloid angiopathy; GENETIC mutation; MENTAL depression; AUSTRIANS; DISEASES
- Publication
Journal of Neural Transmission, 2014, Vol 121, Issue 7, p755
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-014-1179-1