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- Title
Complete response to FOLFOX4 therapy in a patient with advanced urothelial cancer: a case report.
- Authors
Yu Ri Seo; Se Hyung Kim; Hyun Jung Kim; Chan Kyu Kim; Seong Kyu Park; Eun Suk Koh; Dae Sik Hong
- Abstract
No standard has been established for salvage therapy in gemcitabine refractory advanced urothelial cancer. We report the complete response to FOLFOX4 therapy of a metastatic urothelial cancer patient, for whom adjuvant gemcitabine plus cisplatin combination chemotherapy had failed. A 54-year-old male patient with urothelial cancer (transitional cell carcinoma) in the right kidney underwent three rounds of adjuvant gemcitabine-cisplatin chemotherapy after extensive radical nephrectomy. However, he had new liver, lung metastases and synchronous two separate primary colon cancer. The lung metastasis lesion was confirmed as a metastatic urothelial cancer via percutaneous transthoracic needle biopsy (PTNB). Liver and lung metastasis lesions disappeared after the 4th cycle of FOLFOX4 chemotherapy. In addition, colon cancer also disappeared after the 8th cycle of FOLFOX4 chemotherapy. The patient was still showing a complete response after 4 months. Clinical trials using the FOLFOX regimen as salvage therapy for gemcitabine-refractory advanced urothelial cancer are warranted.
- Subjects
CANCER patients; CISPLATIN; LIVER metastasis; COLON cancer; BIOPSY; PRECANCEROUS conditions; DRUG therapy; CLINICAL trials; SALVAGE therapy
- Publication
Journal of Hematology & Oncology, 2010, Vol 3, p1
- ISSN
1756-8722
- Publication type
Article
- DOI
10.1186/1756-8722-3-4