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- Title
The acute-phase response impairs host defence against Enterococcus faecium peritonitis.
- Authors
Leendertse, Masja; Willems, Rob J. L.; Giebelen, Ida A. J.; van den Pangaart, Petra S.; Bonten, Marc J. M.; van der Poll, Tom
- Abstract
Enterococcus faecium is an emerging pathogen that causes infections in hospitalized patients with various co-morbid diseases. These underlying diseases are often associated with an acute-phase response that renders patients vulnerable to nosocomial infections. To study the influence of the acute-phase response induced by sterile tissue injury on host defence against E. faecium, mice were injected subcutaneously with either turpentine or casein 1 day before intraperitoneal infection with E. faecium. Control mice were subcutaneously injected with saline or sodium bicarbonate, respectively. Turpentine and casein induced an acute-phase response as reflected by increases in the plasma concentrations of interleukin-6, serum amyloid P and C3. A pre-existent acute-phase response in mice was associated with a strongly reduced capacity to clear E. faecium, resulting in prolonged bacteraemia for several days. The inflammatory response to E. faecium was impaired in mice with an acute-phase response, as shown by reduced capacity to mount a neutrophilic leucocytosis in peripheral blood and by decreased local cytokine concentrations. These data indicate that the acute-phase response impairs host defence against E. faecium, suggesting that this condition may contribute to the increased vulnerability of critically ill patients to enterococcal infections.
- Subjects
ENTEROCOCCUS; PERITONITIS; ENTEROCOCCAL infections; TURPENTINE; CASEINS; INFECTION
- Publication
Immunology, 2009, Vol 128, Issue 1pt2, pe335
- ISSN
0019-2805
- Publication type
Article
- DOI
10.1111/j.1365-2567.2008.02967.x