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- Title
The relationship between the polymorphisms of the CYP17A1 gene and hypertension: A meta-analysis.
- Authors
Dai, Chuan-Fang; Xie, Xiang; Ma, Yi-Tong; Yang, Yi-Ning; Li, Xiao-Mei; Fu, Zhen-Yan; Liu, Fen; Chen, Bang-Dang; Gai, Min-Tao
- Abstract
<bold>Objective: </bold>With the development of genome-wide association studies (GWAS) concerning hypertension, a growing number of susceptibility genes related to hypertension have been revealed. Subsequently, several studies have investigated the association between CYP17A1 rs1004467 heritable variation and hypertension; however, the results have been inconsistent. In this study, a meta-analysis was performed to assess the association between the CYP17A1 rs1004467 polymorphism and hypertension risk.<bold>Methods: </bold>The PubMed, ISI Web of Science and Embase databases as well as China Wanfang, Weipu and the Chinese Journal Full-text Database were used to retrieve all publications from 2005 to 2013 related to case-control studies that reported a link between the risk factors for hypertension and the CYP17A1 polymorphism. All association studies were identified, and a meta-analysis was conducted using the RevMan 5.0 estimate for odds ratios (ORs) to determine whether the A allele predicts hypertension outcomes.<bold>Results: </bold>Three articles including five studies (totaling 4495 patients and 3529 controls) were identified. The overall effect suggested that rs1004467 was significantly associated with hypertension (OR=1.22, 95%CI 1.08-1.38, p=0.001).<bold>Conclusions: </bold>The present meta-analysis confirmed the significant association between a polymorphism of the CYP17A1 gene and hypertension susceptibility. The CYP17A1 A allele should be considered a risk factor for hypertension.
- Publication
Journal of the Renin-Angiotensin-Aldosterone System, 2015, Vol 16, Issue 4, p1314
- ISSN
1470-3203
- Publication type
journal article
- DOI
10.1177/1470320315585683