We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
3-Hidroksipiridin-4-oni (II. dio): Biološka primjena kao kelatora željeza.
- Authors
Car, Ž.; Peroković, V. Petrović; Pisarović, S. Tomić
- Abstract
Selectivity towards trivalent metal cations, especially Fe(III), is the primary basis of a number of 3-hydroxypyridin-4-ones' biological activities. These compounds have high potential in the treatment of iron overload diseases, in various blood pathologies such as thalassemia and hemochromatosis, as well as in the treatment of neurodegenerative diseases, such as Alzheimer's disease. Beside deferiprone, the only 3-hydroxypyridin-4-one based iron(III) chelating agent which has been used clinically for more than 30 years, this review will also present other most significant and potentially biologically active chelators with 3-hydroxypyridin-4-one core.
- Publication
Kemija u Industriji, 2017, Vol 66, Issue 1-2, p16
- ISSN
0022-9830
- Publication type
Article
- DOI
10.15255/KUI.2015.051