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- Title
Local Interrelationships of Cerebral Oxygen Consumption and Glucose Utilization in Normal Subjects and in Ischemic Stroke Patients: A Positron Tomography Study.
- Authors
Baron, J. C.; Rougemont, D.; Soussaline, F.; Bustany, R; Crouzel, C.; Bousser, M. G.; Comar, D.
- Abstract
Summary: With the use of positron emission tomography (PET) and the 15O steady-state-[18F]fluorode-oxyglucose combined method, the local interrelationships between the cerebral metabolic rate for oxygen (CMRO2) and the cerebral metabolic rate for glucose (CMRGlc) were investigated in control subjects and in stroke patients. In addition to the classic in vivo autoradiographic approach, a kinetic method was used to measure CMRGlc because it was expected to be more reliable in cerebral ischemia. In control subjects local coupling between CBF, CMRO2, and CMRGlc was confirmed, and acceptable values for the CMRO2/CMRGlc ratio were found; the latter, however, was lower in white matter than in gray. Uncoupling between CMR02 and CMRGlc was observed in all stroke patients, suggesting that (1) enhanced anaerobic glycolysis occurred both in reper-fused recent infarcts and in chronically ischemic tissue, and (2) substrates other than blood-borne glucose were being oxidized at the borders of recent infarcts. However, methodological uncertainties presently make such observations only tentative. Finally, a coupled depression of CMR02 and CMRGlc was found in the contralateral cerebellum.
- Publication
Journal of Cerebral Blood Flow & Metabolism, 1984, Vol 4, Issue 2, p140
- ISSN
0271-678X
- Publication type
Article
- DOI
10.1038/jcbfm.1984.22