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- Title
Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania.
- Authors
Bristot, Giovana; Ascoli, Bruna M.; Scotton, Ellen; Géa, Luiza P.; Pfaffenseller, Bianca; Kauer-Sant'Anna, Márcia
- Abstract
Objective: To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by lipopolysaccharides (LPS) has a cumulative effect on subsequent stimuli in this model. We also evaluated the action of lithium (Li) on inflammatory and neurotrophic factors. Methods: Adult male Wistar rats were subjected to an animal model of mania. After the open-field test, they were given LPS to induce systemic immune activation. Subsequently, the animals' blood was collected, and their serum levels of brain-derived neurotrophic factor and inflammatory markers (tumor necrosis factor [TNF]-α, interleukin [IL]-6, IL-1β, IL-10, and inducible nitric oxide synthase [iNOS]) were measured. Results: LDX induced hyperactivity in the animals, but no inflammatory marker levels increased except brain-derived neurotrophic factor (BDNF). Li had no effect on serum BDNF levels but prevented iNOS levels from increasing in animals subjected to immune activation. Conclusion: Although Li prevented an LPS-induced increase in serum iNOS levels, its potential antiinflammatory effects in this animal model of mania were conflicting.
- Subjects
BRAIN-derived neurotrophic factor; ANIMAL models in research; NITRIC-oxide synthases; TUMOR necrosis factors; MANIA
- Publication
Brazilian Journal of Psychiatry / Revista Brasileira de Psiquiatria, 2019, Vol 41, Issue 5, p419
- ISSN
1516-4446
- Publication type
Article
- DOI
10.1590/1516-4446-2017-0001