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- Title
Antimicrobial activity of some isatin-3--thiosemicarbazone complexes.
- Authors
Konstantinović, Sandra S.; Radovanović, Blaga C.; Sovilj, Sofija P.; Stanojević, Svetlana
- Abstract
Isatin-3-thiosemicarbazone complexes with Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and Pd(II) were synthesized and evaluated for their antimicrobial activity against 7 pathogenic bacteria and 4 fungi. The complexes have an enhanced activity compared to the ligand due to transition metal involved in coordination. The anti-amoebic activity in vitro was evaluated against the HM1:IMSS strain of Entamoeba histolytica and the results were compared with the standard drug, metronidazole. The preliminary test results showed that the complexes had better anti-amoebic activity than their respective ligands. Moreover, the complexes showed better inhibition of the test organism.
- Subjects
THIOSEMICARBAZONES; ORGANOSULFUR compounds; PATHOGENIC bacteria; PATHOGENIC microorganisms; ENTAMOEBA histolytica; ENTAMOEBA
- Publication
Journal of the Serbian Chemical Society, 2008, Vol 73, Issue 1, p7
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC0801007K