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- Title
Penehyclidine mitigates postoperative nausea and vomiting and intraoperative oculocardiac reflex in patients undergoing strabismus surgery: a prospective, randomized, double-blind comparison.
- Authors
Sun, Jiacheng; Cao, Xiaofei; Lu, Ting; Li, Nan; Min, Xinxu; Ding, Zhengnian
- Abstract
Background: Postoperative nausea and vomiting (PONV) is one of the most frequent complications following strabismus surgery. Penehyclidine, an anticholinergic agent, is widely used as premedication. This study investigated the effect of preoperative penehyclidine on PONV in patients undergoing strabismus surgery. Methods: In this prospective, randomized, double-blind study, patients scheduled for strabismus surgery under general anesthesia were randomly assigned to either penehyclidine (n = 114) or normal saline (n = 104) group. Penehyclidine was administrated immediately after anesthesia induction, and normal saline was substituted as control. PONV was investigated from 0 to 48 h after surgery. Intraoperative oculocardiac reflex (OCR) was also recorded. Results: Compared with normal saline, penehyclidine significantly reduced PONV incidence (30.7% vs. 54.8%, P < 0.01) and mitigated PONV severity as indicated by severity scoring (P < 0.01). Compared with normal saline, penehyclidine also significantly reduced OCR incidence (57.9% vs. 77.9%, P < 0.01) and mitigated OCR severity, as indicated by the requirement for atropine rescue (77.3% vs. 90.1%, P < 0.05) and the maximum decrease of heart rate during OCR (23.1 ± 9.4 bpm vs. 27.3 ± 12.4 bpm, P < 0.05). The recovery course did not differ between groups. Conclusions: Penehyclidine administrated after anesthesia induction significantly reduced the incidence of PONV and alleviated intraoperative OCR in patients undergoing strabismus surgery. Trial registration: ClinicalTrials.gov (NCT04054479). Retrospectively registered August 13, 2019.
- Subjects
STRABISMUS surgery; PREVENTION of surgical complications; COMPARATIVE studies; CONVALESCENCE; HEART beat; LONGITUDINAL method; INTRAOPERATIVE care; PARASYMPATHOMIMETIC agents; PATIENTS; PHYSIOLOGIC salines; PREANESTHETIC medication; REFLEXES; STATISTICAL sampling; SURGERY; RANDOMIZED controlled trials; TREATMENT effectiveness; BLIND experiment; DESCRIPTIVE statistics; GENERAL anesthesia; PHARMACODYNAMICS
- Publication
BMC Anesthesiology, 2021, Vol 21, Issue 1, p1
- ISSN
1471-2253
- Publication type
Article
- DOI
10.1186/s12871-021-01266-0