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- Title
Expanded profiling of β-lactam selectivity for penicillin-binding proteins in Streptococcus pneumoniae D39.
- Authors
Sharan, Deepti; Carlson, Erin E.
- Abstract
To understand the correlation of our PBP inhibition profiles with cell death, we determined the minimum inhibitory concentration (MIC) for each of the antibiotics used in the present study and compared them to the corresponding IC SB 50 sb values found with each antibiotic for every individual PBP. Keywords: -lactams; activity-based probes; antibiotics; penicillin-binding proteins EN -lactams activity-based probes antibiotics penicillin-binding proteins 433 443 11 03/11/22 20220301 NES 220301 Introduction Antimicrobial resistance is one of the major challenges to global health due to the emergence of multidrug resistant bacteria ([33]). Out of 16 antibiotics tested, eight antibiotics among the penicillin and cephalosporin subclasses showed co-selectivity towards PBP2x along with PBP3. All 16 antibiotics tested have been placed according to their PBP inhibitions, here x-axis and y-axis are different PBPs and the antibiotics that are placed on the diagonal represent specific binding, e.g., cefixime was found to be selective for PBP3 but ertapenem was found to be co-selective for PBP3 and PBP1a.
- Subjects
PENICILLIN-binding proteins; BETA lactam antibiotics; STREPTOCOCCUS pneumoniae; ANTIBIOTICS; BENZYL group; BACTERIAL cell walls; MULTIDRUG resistance in bacteria
- Publication
Biological Chemistry, 2022, Vol 403, Issue 4, p433
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/hsz-2021-0386