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- Title
Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength.
- Authors
Chang, Gregory; Hotca-Cho, Alexandra; Rusinek, Henry; Honig, Stephen; Mikheev, Artem; Egol, Kenneth; Regatte, Ravinder; Rajapakse, Chamith
- Abstract
Introduction: Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength. Methods: This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus. Results: Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively. Conclusion: The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.
- Subjects
FEMUR; FINITE element method; OSTEOPOROSIS; STIFFNESS (Mechanics); ELASTIC modulus; MAGNETIC resonance imaging
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2015, Vol 28, Issue 4, p407
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-014-0475-y