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- Title
Resistive pulse sensing as particle counting and sizing method in microfluidic systems: Designs and applications review.
- Authors
Vaclavek, Tomas; Prikryl, Jan; Foret, Frantisek
- Abstract
Resistive pulse sensing is a well‐known and established method for counting and sizing particles in ionic solutions. Throughout its development the technique has been expanded from detection of biological cells to counting nanoparticles and viruses, and even registering individual molecules, e.g., nucleotides in nucleic acids. This technique combined with microfluidic or nanofluidic systems shows great potential for various bioanalytical applications, which were hardly possible before microfabrication gained the present broad adoption. In this review, we provide a comprehensive overview of microfluidic designs along with electrode arrangements with emphasis on applications focusing on bioanalysis and analysis of single cells that were reported within the past five years.
- Subjects
PARTICLE counting (Water treatment plants); MICROFLUIDIC devices; IONIC liquids; SOLUTION (Chemistry); NUCLEIC acids; NUCLEOTIDES
- Publication
Journal of Separation Science, 2019, Vol 42, Issue 1, p445
- ISSN
1615-9306
- Publication type
Article
- DOI
10.1002/jssc.201800978