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- Title
The interfacial interactions of nanomaterials with human serum albumin.
- Authors
He, Min; Zhang, Wenxiang; Liu, Zheyi; Zhou, Lingqiang; Cai, Xiaoming; Li, Ruibin; Pan, Yuanjiang; Wang, Fangjun
- Abstract
The fates of nanomaterials (NMs) in vivo are greatly dependent on their interactions with human serum proteins. However, the interfacial molecular details of NMs-serum proteins are still difficult to be probed. Herein, the molecular interaction details of human serum albumin (HSA) with Au and SiO2 nanoparticles have been systematically interrogated and compared by using lysine reactivity profiling mass spectrometry (LRP-MS). We demonstrated the biocompatibility of Au is better than SiO2 nanoparticles and the NMs surface charge state played a more important role than particle size in the combination of NMs-HSA at least in the range of 15–40 nm. Our results will contribute to the fundamental mechanism understanding of NMs-serum protein interactions as well as the NMs rational design.
- Subjects
SERUM albumin; SOCIAL interaction; BLOOD proteins; MOLECULAR interactions; GOLD nanoparticles; SURFACE charges
- Publication
Analytical & Bioanalytical Chemistry, 2022, Vol 414, Issue 16, p4677
- ISSN
1618-2642
- Publication type
Article
- DOI
10.1007/s00216-022-04089-1