We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Stepwise arteriovenous fate acquisition during mammalian vasculogenesis.
- Authors
Chong, Diana C.; Koo, Yeon; Xu, Ke; Fu, Stephen; Cleaver, Ondine
- Abstract
Arteriovenous (AV) differentiation is a critical step during blood vessel formation and stabilization. Defects in arterial or venous fate lead to inappropriate fusion of vessels, resulting in damaging arteriovenous shunts. While many studies have unraveled the molecular underpinnings that drive AV fate, surprisingly, the spatiotemporal emergence of arteries and veins in mammalian embryos remains unknown. Here, we examine artery and vein specification and differentiation during vasculogenesis. We show that the first intraembryonic vessels formed are arteries, which differentiate in a stepwise manner. By contrast, veins emerge later, progressively forming after embryonic turning. In addition, we demonstrate that hemodynamic flow is not required for arterial specification, but is required for maintenance of select arterial markers. Together, our results provide a first spatiotemporal analysis of mammalian AV cell fate establishment and anatomy, as well as a delineation of a molecular toolkit for analysis of arteries and veins during early vessel development. Developmental Dynamics 240:2153-2165, 2011. © 2011 Wiley-Liss, Inc.
- Publication
Developmental Dynamics, 2011, Vol 240, Issue 9, p2153
- ISSN
1058-8388
- Publication type
Article
- DOI
10.1002/dvdy.22706