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- Title
Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy.
- Authors
Jakubaszek, Marta; Rossier, Jeremie; Karges, Johannes; Delasoie, Joachim; Goud, Bruno; Gasser, Gilles; Zobi, Fabio
- Abstract
The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells.
- Subjects
PHOTODYNAMIC therapy; VITAMIN B12; PHOTOSENSITIZERS; CANCER cells; INORGANIC chemistry
- Publication
Helvetica Chimica Acta, 2019, Vol 102, Issue 7, pN.PAG
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201900104