We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Trichodermates A-F, New Cytotoxic Trichothecenes from the Plant Pathogenic Fungus Trichoderma sp.
- Authors
Li, Jiaying; Ren, Jinwei; Bao, Li; Jin, Tao; Wang, Wenzhao; Pei, Yunfei; Liu, Xingzhong; Li, Erwei
- Abstract
Trichodermates A - F ( 1- 6, resp.), six new trichothecene polyunsaturated octadioic acid esters, and (−)-harzianum B ( 7) were isolated from the fermentation extract of Trichoderma sp., a plant pathogenic fungus isolated from stem rot of an unidentified tree in Thailand. The structures of 1- 7 were elucidated by NMR experiments. The absolute configuration at C(12) in 3 was assigned by in situ dimolybdenum circular dichroism method, whereas that in 7 was deduced after hydrolysis of 7 to 8 via modified Mosher's method. Compounds 1 and 2 showed modest cytotoxic activities against the K562 (human myelogenous leukemia) cell line with IC50 values of 12.12 and 13.08 μ M, respectively.
- Subjects
TRICHOTHECENES; MYCOTOXINS; TERPENES; TRICHODERMA; MONILIACEAE; CHEMICAL synthesis; CHEMICAL bonds; CHEMICAL structure
- Publication
Helvetica Chimica Acta, 2016, Vol 99, Issue 1, p63
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201500182