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- Title
The First Stereoselective Total Synthesis of Naturally Occurring, Bioactive (3 R,5 R)-1-(4-Hydroxyphenyl)-7-phenylheptane-3,5-diol and the Synthesis of Its Enantiomer.
- Authors
Reddy, Parigi Raghavendar; Sudhakar, Chithaluri; Kumar, Jayprakash Narayan; Das, Biswanath
- Abstract
The first stereoselective total synthesis of the naturally occurring anti-emetic diarylheptanoid (3 R,5 R)-1-(4-hydroxyphenyl)-7-phenylheptane-3,5-diol ( 1) was accomplished starting from 4-hydroxybenzaldehyde and involving a Sharpless kinetic resolution and an asymmetric epoxidation as the key steps ( Scheme 2). The enantiomer 1a of this compound was also simultaneously prepared.
- Subjects
STEREOSELECTIVE reactions; STEREOCHEMISTRY; STERIC hindrance; EMETICS; EPOXIDATION; ENANTIOMERS
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 2, p289
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201200165