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- Title
Determining amlodipine in blood plasma by liquid chromatography coupled to tandem mass spectrometry.
- Authors
Miroshnichenko, I. I.; Lelishentsev, A. A.; Kalmykov, Yu. M.; Fedotov, Yu. A.; Ivashchenko, A. A.
- Abstract
Asimple and rapid high-performance liquid chromatography (HPLC) method with tandem mass spectrometry (TMS) detectoin has been developed for the determination of amlodipine in blood plasma. The HPLC system is coupled to a TMS detector via an electrospray ionization (ESI) interface in the positive-ion mode. The plasma samples were extracted either with a diethylether:hexane (8:2, v/v) mixture of by means of solid-phase extraction with Oasis HLB 1-cc cartridges (Waters, USA). The analytes were chromatographed under reversed-phase conditions on a Zorbax 300 SB-C18 column. The proposed HPLC/TMS procedure was successfully used for the study of the clinical pharmacokinetics of amlodipine and other calcium-channel blockers.
- Subjects
BLOOD plasma; LIQUID chromatography; CHROMATOGRAPHIC analysis; AMLODIPINE; SPECTROMETRY
- Publication
Pharmaceutical Chemistry Journal, 2008, Vol 42, Issue 8, p493
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-008-0158-y