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- Title
Methotrexate‑associated B‑cell lymphoproliferative disease that exhibits hematuria due to urinary bladder lesions: A case report.
- Authors
Manabe, Masahiro; Nagano, Yuki; Okuno, Takahiro; Inoue, Takeshi; Koh, Ki-Ryang
- Abstract
Methotrexate (MTX)-related lymphoproliferative disease (LPD) is one of the most prominent late complications associated with MTX treatment. Although MTX-related LPD exhibits a relatively high incidence of extranodal disease, the incidence of disease in a urinary bladder is very low. The present study reports the case of a patient with MTX-related LPD involving a urinary bladder mass. A 75-year-old female patient, who had been receiving MTX for ~15 years, was referred to the hospital due to fever and hematuria. A computed tomography scan revealed the thickening of the urinary bladder wall, hydronephrosis and lymph node swelling. The histopathological findings of the urinary bladder mass resulted in a diagnosis of MTX-related LPD. Although MTX withdrawal did not have any effect, the subsequent chemotherapy resulted in complete remission. Although MTX-related LPD in the bladder is rare, it is pertinent to consider MTX-related LPD when hematuria is observed during MTX therapy.
- Subjects
BLADDER injuries; RISK assessment; LYMPH nodes; BIOPSY; CYSTOSCOPY; METHOTREXATE; COMPUTED tomography; EDEMA; HEMATURIA; FEVER; IMMUNOHISTOCHEMISTRY; LYMPHOPROLIFERATIVE disorders; HYDRONEPHROSIS; STAINS &; staining (Microscopy); B cell lymphoma; CEFTRIAXONE; DISEASE risk factors; SYMPTOMS
- Publication
Medicine International (2754-3242), 2024, Vol 4, Issue 4, pN.PAG
- ISSN
2754-3242
- Publication type
Article
- DOI
10.3892/mi.2024.168