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- Title
Infantile Tremor Syndrome Followed by West Syndrome: Effect or Continuation of Spectrum?
- Authors
Azad, Chandrika; Singh, Jasmine; Guglani, Vishal
- Abstract
<bold>Background: </bold>Infantile tremor syndrome (ITS) is a nutritional deficiency syndrome, frequently reported from the Indian subcontinent caused by vitamin B12 deficiency. The West syndrome (WS), on the other hand, is a type of epileptic encephalopathy with variable etiology.<bold>Case Series: </bold>We present a series of five children who presented with symptoms consistent with ITS and received standard intramuscular vitamin B12 therapy to which good response was observed. All these children were readmitted with WS with a time lag varying from 2 to 12 months. Magnetic resonance imaging brain and metabolic screen were within normal limits. Three out of five patients responded well to adrenocorticotropic hormone (ACTH), remaining two required additional drugs. We hypothesize that WS could have developed after ITS due to developmental desynchronization.<bold>Conclusion: </bold>In the Indian scenario, it is particularly important to be aware of appearance of WS after ITS, because of high prevalence of ITS and devastating nature of WS.
- Subjects
SOUTH Asia; VITAMIN B12; ADRENOCORTICOTROPIC hormone; TREMOR; MALNUTRITION; VITAMIN deficiency
- Publication
Journal of Tropical Pediatrics, 2020, Vol 66, Issue 5, p556
- ISSN
0142-6338
- Publication type
journal article
- DOI
10.1093/tropej/fmaa014