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- Title
Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry.
- Authors
Lee, Kyung Min; Nelson, Tyler J; Bryant, Alex; Teerlink, Craig C; Gulati, Roman; Pagadala, Meghana S; Tcheandjieu, Catherine; Pridgen, Kathryn M; DuVall, Scott L; Yamoah, Kosj; Vassy, Jason L; Seibert, Tyler M; Hauger, Richard L; Rose, Brent S; Lynch, Julie A
- Abstract
Despite differences in prostate cancer risk across ancestry groups, relative performance of prostate cancer genetic risks scores (GRS) for positive biopsy prediction in different ancestry groups is unknown. This cross-sectional retrospective analysis examines the association between a polygenic hazard score (PHS290) and risk of prostate cancer diagnosis upon first biopsy in male veterans using 2-sided tests. Our analysis included 36 717 veterans (10 297 of African ancestry). Unadjusted rates of positive first prostate biopsy increased with higher genetic risk (low risk: 34%, high risk: 58%; P < .001). Among men of African ancestry, higher genetic risk was associated with increased prostate cancer detection on first biopsy (odds ratio = 2.18, 95% confidence interval = 1.93 to 2.47), but the effect was stronger among men of European descent (odds ratio = 3.89, 95% confidence interval = 3.62 to 4.18). These findings suggest that incorporating genetic risk into prediction models could better personalize biopsy decisions, although further study is needed to achieve equitable genetic risk stratification among ancestry groups.
- Subjects
PROSTATE cancer; EARLY detection of cancer; PROSTATE biopsy; CIRCULATING tumor DNA; GENEALOGY; CANCER diagnosis; DISEASE risk factors
- Publication
JNCI: Journal of the National Cancer Institute, 2024, Vol 116, Issue 5, p753
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djae002