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- Title
Cumulative incidence of anal cancer since HIV or AIDS diagnosis in the United States.
- Authors
Haas, Cameron B; Engels, Eric A; Horner, Marie-Josèphe; Pfeiffer, Ruth M; Luo, Qianlai; Kreimer, Aimée R; Palefsky, Joel M; Shiels, Meredith S
- Abstract
Treatment of screen-detected anal high-grade squamous intraepithelial lesions has been shown to effectively reduce the incidence of invasive anal cancer in people with HIV. We provide population-based estimates of cumulative incidence of anal cancer by risk group and age at HIV or AIDS diagnosis. The 0- to 10-year cumulative incidence of anal cancer for men who have sex with men and are younger than 30 years of age at HIV diagnosis was 0.17% (95% confidence interval [CI] = 0.13% to 0.20%) compared with 0.04% (95% CI = 0.02% to 0.06%) in other men and 0.03% (95% CI = 0.01% to 0.04%) in women. For men who have sex with men and have a diagnosis of AIDS and are younger than 30 years of age, the 0- to 10-year cumulative incidence was 0.35% (95% CI = 0.28% to 0.41%). Among people with HIV, men who have sex with men are at the greatest risk of anal cancer, and those with a diagnosis of AIDS had higher risk than those without AIDS. These estimates may inform recommendations for priority populations that could benefit most from anal cancer screening and treatment.
- Subjects
UNITED States; ANAL cancer; AIDS; HIV
- Publication
JNCI: Journal of the National Cancer Institute, 2023, Vol 115, Issue 10, p1227
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djad128