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- Title
PKB/Akt-Dependent Regulation of Cell Motility.
- Authors
Gongda Xue; Hemmings, Brian A.
- Abstract
The prosurvival activity of phosphoinositide 3 kinase (PI3K)/Akt (also known as protein kinase B, PKB) pathway has been investi-gated in great detail in human physiology and disease. Accumulating evidence is emerging that this signaling axis also actively engages with the migratory process in motile cells, including metastatic cancer cells. Interference with the role of PI3K/Akt-medi-ated cell motility impairs cellular development and attenuates malignant progression of cancer metastasis. Because metastasis is responsible for 90% of mortality in cancer patients, the acceleration of cancer cell spreading observed in association with hyper-activation of the PI3K pathway, triggered for example by chemotherapy/radiotherapy in the clinic, has heightened awareness of the conflict between "good drugs" and unfavorable effects. Here, we discuss recent studies on PI3K/Akt-regulated cell motility in both physiological and pathological settings, with the aim of a better understanding of how activities of the PI3K/Akt axis initiate and transmit "migratory signals" that stimulate cell movement. We focus in particular on its direct influence on cell migration and invasion, epithelial-mesenchymal transition, and cancer metastasis.
- Subjects
PROTEIN kinase B; PHOSPHOINOSITIDES; HUMAN physiology; CELLULAR signal transduction; CANCER cells; CELL motility; METASTASIS
- Publication
JNCI: Journal of the National Cancer Institute, 2013, Vol 105, Issue 6, p393
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djs648