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- Title
An investigation of antibacterial effects of steroids.
- Authors
DOĞAN, Abdullah; OTLU, Salih; ÇELEBİ, Özgür; AKSU KILIÇLE, Pınar; GÜLMEZ SAĞLAM, Aliye; Can DOĞAN, Ali Nazmi; MUTLU, Neslihan
- Abstract
In this study, the effects of steroid substances such as corticosterone, progesterone, estrone, beta-sitosterol, and stigmasterol on some bacteria were investigated. In the research, standard strains of the gram-positive bacteria Bacillus subtilis (lab isolate) and Staphylococcus aureus (ATCC 6538) and the gram-negative bacteria Escherichia coli (ATCC 25922), Pasteurella multocida (ATCC 12945), and Pseudomonas aeruginosa (ATCC 9027) were used. A modified broth dilution method was applied for determining the minimal inhibitory concentration (MIC) of the steroids. Mueller Hinton broth (Becton Dickinson, 211443) was used to prepare dilutions and as a medium. At the end of the study, the MIC of corticosterone for P. multocida and the MIC of beta-sitosterol for S. aureus were both determined as 32 µg/mL. However, other steroids showed no effects on the bacteria. These steroids did not appear to have widespread antibacterial properties.
- Subjects
STEROIDS; ADRENOCORTICAL hormones; GRAM-positive bacteria; BACILLUS subtilis; STAPHYLOCOCCUS aureus
- Publication
Turkish Journal of Veterinary & Animal Sciences, 2017, Vol 41, Issue 2, p302
- ISSN
1300-0128
- Publication type
Article
- DOI
10.3906/vet-1510-24