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- Title
Synthesis and Antiviral Activity of New Dimeric 1,2,3-Triazolyl Pyrimidine Nucleoside Analogues.
- Authors
Andreeva, O. V.; Saifina, L. F.; Shulaeva, M. M.; Belenok, M. G.; Zarubaev, V. V.; Slita, A. V.; Volobueva, A. S.; Semenov, V. E.; Kataev, V. E.
- Abstract
A series of new dimers of pyrimidine nucleoside analogues have been synthesized. The dimers are composed of two uracil or thymine fragments linked at N3 through a polymethylene bridge and bearing a β-D-ribofuranose residue linked to N1 of the nucleobase through a 1,2,3-triazolylalkyl spacer. Biological screening revealed that some of the synthesized dimers are active against influenza A (H1N1) virus and coxsackievirus B3 with IC50 values of 13 and 4.5 μM, respectively.
- Subjects
PYRIMIDINES; BRIDGE bearings; PYRIMIDINE nucleosides; DIMERS; URACIL; POLYMETHYLENE
- Publication
Russian Journal of Organic Chemistry, 2024, Vol 60, Issue 4, p576
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428024040031