We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficient Synthesis and Antimicrobial Evaluation of Acyclic Pyrimidine Nucleosides and Their Sulfanyl Analogs.
- Authors
Alkabli, J.; Moustafa, A. H.
- Abstract
A facile synthetic approach has been proposed for a new series of uracil acyclic nucleosides and their sulfanyl analogs via reaction of pyrimidine derivatives with a number of acyclic halides such as 4-bromobutyl acetate, 2-(bromomethoxy)ethyl acetate, 3-chloropropan-1-ol, epichlorohydrin, allyl bromide, and propargyl bromide). The desired products were obtained in good yields (68–90%) at room temperature in the presence of potassium carbonate. Some of the synthesized compounds showed significant antibacterial activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa (inhibition zone diameter 19–29 mm compared to 21–26 mm for Ampicillin taken as reference drug).
- Subjects
PYRIMIDINE nucleosides; URACIL derivatives; PROPARGYL bromide; ETHYL acetate; BACILLUS cereus; POTASSIUM carbonate
- Publication
Russian Journal of Organic Chemistry, 2022, Vol 58, Issue 3, p385
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428022030186