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- Title
Synthesis of 5-nitro-3,4-dihydropyrimidin-2(1 H)-ones catalyzed by metal salts. Retro-Henry reaction with formation of N,N′-disubstituted ureas.
- Authors
Sedova, V.F.; Krivopalov, V.P.; Shkurko, O.P.
- Abstract
Three-component condensation of α-nitroacetophenone with aromatic aldehydes and urea in the presence of iron(III), cobalt(II), nickel(II), and copper(II) salts as catalyst led to the formation of 4,6-diaryl-5-nitro-3,4-dihydropyrimidin-2(1 H)-ones and N-benzoyl- N′-(1-aryl-2-nitroethyl)ureas. The latter were formed as a result of retro-nitroaldol (retro-Henry) reaction of intermediate 4,6-diaryl-6-hydroxy-5-nitro-3,4,5,6-tetra-hydropyrimidin-2(1 H)-ones.
- Subjects
ORGANIC synthesis; CATALYSIS; UREA; CHEMICAL reactions; ALDEHYDES
- Publication
Russian Journal of Organic Chemistry, 2007, Vol 43, Issue 1, p90
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S1070428007010113