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- Title
The Combined Effect of Age, Education, and Stroke on Dementia and Cognitive Impairment No Dementia in the Elderly.
- Authors
De Ronchi, Diana; Palmer, Katie; Pioggiosi, Philippe; Atti, Anna Rita; Berardi, Domenico; Ferrari, Barbara; Dalmonte, Edoardo; Fratiglioni, Laura
- Abstract
Background: This study aims to detect the impact of stroke on the occurrence of dementia and cognitive impairment/no dementia (CIND) in different age, sex, and education groups. Methods: Persons with dementia (DSM-III-R) or CIND were identified by a two-phase study design among 7,930 persons from the population-based Faenza Community Aging Study. Results: Subjects with a history of stroke had increased risk of both dementia [risk ratio (RR) = 3.7; 95% confidence interval (CI) = 3.1–4.4] and CIND (RR = 1.7, 95% CI = 1.4–2.2). These associations were stronger in the younger-old (61–74 years) than in the older-old (75+ years), and among higher-educated (4+ years) than lower-educated (0–3 years of schooling) persons. Dementia and CIND prevalence among stroke subjects was similar to the prevalence detected among subjects 10 years older but without a history of stroke. In stroke subjects, dementia prevalence became higher than CIND prevalence 10 years earlier than in non-stroke subjects. A combined effect for dementia due to a history of stroke, increasing age, and decreasing years of schooling was detected. Conclusions: Stroke is a strong risk factor for dementia among younger-old and higher-educated subjects; in the presence of a stroke, dementia onset might occur about 10 years earlier, possibly by accelerating the progression from CIND to dementia. Copyright © 2007 S. Karger AG, Basel
- Subjects
DEMENTIA; CEREBROVASCULAR disease; COGNITION disorders; OLDER people; AGING
- Publication
Dementia & Geriatric Cognitive Disorders, 2007, Vol 24, Issue 4, p266
- ISSN
1420-8008
- Publication type
Article
- DOI
10.1159/000107102