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- Title
Serum Levels of Interleukin-13 Increase in Subjects with Insulin Resistance but Do Not Correlate with Markers of Low-Grade Systemic Inflammation.
- Authors
Martínez-Reyes, Camilo P.; Gómez-Arauz, Angélica Y.; Torres-Castro, Israel; Manjarrez-Reyna, Aarón N.; Palomera, León F.; Olivos-García, Alfonso; Mendoza-Tenorio, Edith; Sánchez-Medina, Gabriela A.; Islas-Andrade, Sergio; Melendez-Mier, Guillermo; Escobedo, Galileo
- Abstract
Experimental evidence in mice suggests a role for interleukin- (IL-) 13 in insulin resistance and low-grade systemic inflammation. However, IL-13 serum levels have not been assessed in subjects with insulin resistance, and associations of IL-13 with parameters of low-grade systemic inflammation are still unknown. Our main goal was to examine the systemic levels of IL-13 in patients with insulin resistance, while also studying the relationship of IL-13 with anthropometric, metabolic, and low-grade systemic inflammatory markers. Ninety-two participants were included in the study and divided into insulin-resistant patients and noninsulin-resistant controls. Blood levels of IL-13, glucose, insulin, triglycerides, cholesterol, tumor necrosis factor-alpha (TNF-<italic>α</italic>), IL-10, proinflammatory (Mon-CD11c+CD206−), and anti-inflammatory (Mon-CD11c−CD206+) monocytes, as well as anthropometric parameters, were measured in all volunteers. Insulin-resistant patients showed 2.5-fold higher serum levels of IL-13 than controls (P<0.0001) and significantly increased values of TNF-<italic>α</italic> and Mon-CD11c+CD206−, with concomitant reductions in IL-10 and Mon-CD11c−CD206+. Increased IL-13 was extraordinarily well associated with hyperglycemia (r=0.7362) and hypertriglyceridemia (r=0.7632) but unexpectedly exhibited no significant correlations with TNF-<italic>α</italic> (r=0.2907), IL-10 (r=−0.3882), Mon-CD11c+CD206− (r=0.2745) or Mon-CD11c−CD206+ (r=−0.3237). This study demonstrates that IL-13 serum levels are elevated in patients with insulin resistance without showing correlation with parameters of low-grade systemic inflammation.
- Subjects
BLOOD serum analysis; INTERLEUKIN-13; INSULIN resistance; BIOMARKERS; INFLAMMATION
- Publication
Journal of Diabetes Research, 2018, p1
- ISSN
2314-6745
- Publication type
Article
- DOI
10.1155/2018/7209872