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- Title
Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing.
- Authors
Drake, Joshua C.; Yan, Zhen
- Abstract
Skeletal muscle is important for overall functionality and health. Ageing is associated with an accumulation of damage to mitochondrial DNA and proteins. In particular, damage to mitochondrial proteins in skeletal muscle, which is a loss of mitochondrial proteostasis, contributes to tissue dysfunction and negatively impacts systemic health. Therefore, understanding the mechanisms underlying the regulation of mitochondrial proteostasis and how those mechanisms change with age is important for the development of interventions to promote healthy ageing. Herein, we examine how impairment in the selective degradation of damaged/dysfunctional mitochondria through mitophagy may play a central role in the loss of mitochondrial proteostasis in skeletal muscle ageing, as well as its broader implications for systemic health. Further, we explore how stimulating mitophagy through exercise may promote healthy ageing.
- Subjects
SKELETAL muscle; MITOCHONDRIAL proteins; MITOCHONDRIAL DNA; AGING; METABOLISM
- Publication
Journal of Physiology, 2017, Vol 595, Issue 20, p6391
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP274337