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- Title
Resting pulmonary haemodynamics and shunting: a comparison of sea-level inhabitants to high altitude Sherpas.
- Authors
Foster, Glen E.; Ainslie, Philip N.; Stembridge, Mike; Day, Trevor A.; Bakker, Akke; Lucas, Samuel J. E.; Lewis, Nia C. S.; MacLeod, David B.; Lovering, Andrew T.
- Abstract
Key points Evolutionary pressure to improve gas exchange and/or resting pulmonary haemodynamics in hypoxic environments may have led to differences in the amount of blood that flows through right-to-left shunt pathways between Sherpas and sea-level inhabitants., We studied sea-level inhabitants during rest at sea level and acute isocapnic hypoxia and during rest at high altitude following 3 weeks of acclimatization and compared their responses to those of Sherpas during rest at high altitude., Contrary to some previous literature, we found similar resting pulmonary pressure and total pulmonary resistance between acclimatized sea-level inhabitants and Sherpas at high altitude., We also found a similar number of subjects from each group with intracardiac shunt and intrapulmonary shunt at high altitude., These results help us better understand resting cardiopulmonary adaptations to high altitude by comparing life-long high altitude residents with sea-level inhabitants acclimatized to high altitude., Abstract The incidence of blood flow through intracardiac shunt and intrapulmonary arteriovenous anastomoses (IPAVA) may differ between Sherpas permanently residing at high altitude (HA) and sea-level (SL) inhabitants as a result of evolutionary pressure to improve gas exchange and/or resting pulmonary haemodynamics. To test this hypothesis we compared sea-level inhabitants at SL (SL-SL; n = 17), during acute isocapnic hypoxia (SL-HX; n = 7) and following 3 weeks at 5050 m (SL-HA; n = 8 non-PFO subjects) to Sherpas at 5050 m ( n = 14).
- Subjects
PARTIAL pressure; PULMONARY artery diseases; CONTROL groups; PULMONARY gas exchange; BLOOD flow
- Publication
Journal of Physiology, 2014, Vol 592, Issue 6, p1397
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2013.266593