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- Title
The Clinical and Pathological Significance of Nectin-2 and DDX3 Expression in Pancreatic Ductal Adenocarcinomas.
- Authors
Shan Liang; Zhulin Yang; Daiqiang Li; Xiongying Miao; Leping Yang; Qiong Zou; Yuan Yuan
- Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a highlymalignant disease, but the genetic basis of PDAC is still unclear. In this study, Nectin-2 and DDX3 expression in 106 PDAC, 35 peritumoral tissues, 55 benign pancreatic lesions, and 13 normal pancreatic tissues were measured by immunohistochemical methods. Results showed that the percentage of positive Nectin-2 and DDX3 expression was significantly higher in PDAC tumors than in peritumoral tissues, benign pancreatic tissues, and normal pancreatic tissues (p < 0.01). The percentage of cases with positive Nectin-2 and DDX3 expression was significantly lower in PDAC patients without lymph node metastasis and invasion and having TNM stage I/II disease than in patients with lymph node metastasis, invasion, and TNM stage III/IV disease (p < 0.05 or p < 0.01). Positive DDX3 expression is associated with poor differentiation of PDAC. Kaplan-Meier survival analysis showed that positive Nectin-2 and DDX3 expression were significantly associated with survival in PDAC patients (p < 0.001). Coxmultivariate analysis revealed that positiveNectin-2 andDDX3 expression were independent poor prognosis factors in PDAC patients. In conclusion, positive Nectin-2 and DDX3 expression are associated with the progression and poor prognosis in PDAC patients.
- Subjects
NECTINS; PANCREATIC cancer; DUCTAL carcinoma; GENE expression; CANCER invasiveness; KAPLAN-Meier estimator; PROGNOSIS
- Publication
Disease Markers, 2015, Vol 2015, p1
- ISSN
0278-0240
- Publication type
Article
- DOI
10.1155/2015/379568