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- Title
Association between triglyceride to HDL-C ratio and insulin resistance in indigenous Argentinean children.
- Authors
Hirschler, V.; Maccallini, G.; Sanchez, M.; Gonzalez, C.; Molinari, C.
- Abstract
Background Insulin resistance is considered one of the major risk factors for the development of type 2 diabetes mellitus ( T2DM). Thus, early identification, preferably by using simple and inexpensive diagnostic tools, is essential for preventing T2DM. Triglyceride ( TG) to high-density lipoprotein cholesterol ( HDL-C) ratio ( TG/ HDL-C) has been proposed as an inexpensive tool to identify individuals at high risk of T2DM. The objective of this study was to determine the relationship between insulin resistance and TG/ HDL-C in indigenous Argentinean children. Methods A cross-sectional study of 501 (243 boys) indigenous school children aged 10.0 ± 2.4 yr were assessed for anthropometry, lipids, glucose, and insulin levels from November 2011 to November 2013. Insulin resistance was defined as the upper third quartile of homeostasis model assessment ( HOMA-IR). Results The prevalence of overweight/obesity was 11.4% per Centers for Disease Control. Mean levels of various characteristics were: body mass index ( BMI) 17.2 ± 2.6, HDL-C 39 ± 9 mg/ dL, TGs 121 ± 58 mg/ dL, TG/ HDL-C 2.9 ± 1.8, glucose 77 ± 8 mg/ dL, HOMA-IR 1.0 ± 0.8, and insulin 44 ± 9 mUI/L. Children in the higher quartiles of TG/ HDL-C had significantly higher HOMA-IR values than children in the lower quartiles. Multiple linear regression analysis showed that TG/ HDL-C was significantly associated with HOMA-IR ( r2 = 0.19) adjusted for age, gender, and BMI. Furthermore, for a 1-unit increase in log TG/ HDL-C, the odds of being insulin resistant ( HOMA-IR> III quartile) increased by 2.58 times [odds ratio ( OR), 2.58 (1.63-4.05); p < 0.01], adjusted for age, gender, and BMI. Conclusion This study suggests that TG/ HDL-C may be a good marker to identify insulin resistant indigenous Argentinean children.
- Subjects
ARGENTINA; SOUTH America; TYPE 2 diabetes risk factors; ANTHROPOMETRY; BLOOD pressure; BLOOD pressure measurement; BLOOD sugar; BODY weight; C-reactive protein; CHOLESTEROL; ETHNIC groups; GENETICS; HIGH density lipoproteins; HOMEOSTASIS; INDIGENOUS peoples; INFORMED consent (Medical law); INSULIN resistance; LIPOPROTEINS; LOW density lipoproteins; PEDIATRICS; RACE; STATISTICS; STATURE; TRIGLYCERIDES; DATA analysis; BODY mass index; CROSS-sectional method; LABORATORY test panels; DESCRIPTIVE statistics
- Publication
Pediatric Diabetes, 2015, Vol 16, Issue 8, p606
- ISSN
1399-543X
- Publication type
Article
- DOI
10.1111/pedi.12228