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- Title
Occult hepatitis B virus infection in liver transplant recipients with recurrent hepatitis C: relationship with donor age and fibrosis progression.
- Authors
Toniutto, Pierluigi; Minisini, Rosalba; Fabris, Carlo; De Feo, Tullia; Marangoni, Francesca; Burlone, Michela; Avellini, Claudio; Bitetto, Davide; Fornasiere, Ezio; Fumolo, Elisa; Baccarani, Umberto; Pirisi, Mario
- Abstract
Liver transplantation (OLT) recipients who receive a graft from donors positive for hepatitis B virus (HBV) anti-core antibodies may develop overt “ de novo” HBV infection. The study was undertaken to explore how often HBV infection may remain occult after OLT for hepatitis C, and whether it may represent a factor of graft fibrosis progression. We studied 30 consecutive patients transplanted for hepatitis C liver disease. Specimens from the native liver and from the graft were searched for occult HBV infection (O-HBV). In the native liver, 8/30 patients had detectable O-HBV; during the follow-up, O-HBV infection was demonstrated in 14 graft specimens. Graft O-HBV was associated with older donor age (≥50 yr; 8/9 vs. 6/21, p < 0.005). Recipients with graft O-HBV and no O-HBV in the native liver who received their grafts from donors aged >40 yr had faster fibrosis progression than recipients with no post-transplant O-HBV, whose grafts came from donors aged >40 yr and recipients whose grafts came from donors aged ≤40 yr (4/7 vs. 1/7 vs. 2/16, p < 0.05). In OLT recipients, O-HBV is more likely to occur when grafts are obtained from aged donors and may affect the rate of fibrosis progression because of recurrent hepatitis C.
- Subjects
LIVER diseases; ORGAN donation; VIRAL hepatitis; HEPATITIS B; HEPATITIS B virus
- Publication
Clinical Transplantation, 2009, Vol 23, Issue 2, p184
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1111/j.1399-0012.2009.00964.x