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- Title
Impulse control disorders in Parkinson's disease: Crossroads between neurology, psychiatry and neuroscience.
- Authors
Bugalho, Paulo; Oliveira-Maia, Albino J.
- Abstract
Non-motor symptoms contribute significantly to Parkinson's disease (PD) related disability. Impulse control disorders (ICDs) have been recently added to the behavioural spectrum of PD-related non-motor symptoms. Such behaviours are characterized by an inappropriate drive to conduct repetitive behaviours that are usually socially inadequate or result in harmful consequences. Parkinson disease impulse control disorders (PD-ICDs) have raised significant interest in the scientific and medical community, not only because of their incapacitating nature, but also because they may represent a valid model of ICDs beyond PD and a means to study the physiology of drive, impulse control and compulsive actions in the normal brain. In this review, we discuss some unresolved issues regarding PD-ICDs, including the association with psychiatric co-morbidities such as obsessive-compulsive disorder and with dopamine related side effects, such as hallucinations and dyskinesias; the relationship with executive cognitive dysfunction; and the neural underpinnings of ICDs in PD. We also discuss the contribution of neuroscience studies based on animal-models towards a mechanistic explanation of the development of PD-ICDs, specifically regarding corticostriatal control of goal directed and habitual actions.
- Subjects
IMPULSE control disorders; PARKINSON'S disease; NEUROLOGY; NEUROSCIENCES; PSYCHIATRY; SYMPTOMS
- Publication
Behavioural Neurology, 2013, Vol 27, Issue 4, p547
- ISSN
0953-4180
- Publication type
Article
- DOI
10.1155/2013/826742