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- Title
Hypokalemic Sensory Overstimulation.
- Authors
Segal, Michael M.; Rogers, Gary F.; Needleman, Howard L.; Chapman, Catherine A.
- Abstract
This report describes 2 generations of a family with symptoms of sensory overstimulation that exhibit a potassium sensitivity similar to that seen in hypokalemic periodic paralysis. The sensory overstimulation is characterized by a subjective experience of sensory overload and a relative resistance to lidocaine local anesthesia. The sensory overload is treatable with oral potassium gluconate, with onset of the therapeutic effect in ~20 minutes. The effect of potassium is reminiscent of its effect in the channelopathies underlying hypokalemic periodic paralysis, and the resistance to lidocaine applied peripherally suggests a peripheral sensory localization to the abnormality The phenotype overlaps with that of attention deficit disorder, raising the possibility of subtypes of attention deficit disorder that have a peripheral sensory cause and novel forms of therapy.
- Subjects
HYPOKALEMIA; POTASSIUM metabolism disorders; WATER-electrolyte imbalances; LIDOCAINE; PHENOTYPES; POTASSIUM; PARALYSIS; LOCAL anesthetics
- Publication
Journal of Child Neurology, 2007, Vol 22, Issue 12, p1408
- ISSN
0883-0738
- Publication type
Article
- DOI
10.1177/0883073807307095